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Successful treatment of inorganic mercury neurotoxicity with N-acetyl-penicillamine despite an adverse reaction

From the Department of Neurology, Montefiore Hospital and Medical Center, and the Department of Neurology and Pathology (Neuropathology) and the Institute of Neurotoxicology, Albert Einstein College of Medicine, Bronx, NY.

A man developed tremor after prolonged occupational exposure to metallic mercury. Treatment with N-acetyl-penicillamine resulted in marked clinical improvement despite untoward side effects. These side effects resolved after antihistamine treatment and conclusion of therapy. The decision to complete the therapeutic regimen despite an adverse reaction was justified by the striking clinical improvement.

This work was supported in part by USPHS Grants Nos. NS 03356, OH 00535, and ES 02168, and Grant No. PFR 78120 from the National Science Foundation.

Address correspondence and reprint requests to Dr. Schaumburg, Albert Einstein College of Medicine, 1300 Moms Park Avenue, Bronx, NY 10461.

Accepted for publication December 10, 1979.