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Fatal Guillain-Barré syndrome after the national influenza immunization program

From the Center for Disease Control, Atlanta, GA.

Fifty-eight fatal cases of Guillain-Barré syndrome (GBS) were reported during the 1976 to 1977 National Influenza Program: Thirty-two (58%) of these patients had received the A/New Jersey influenza vaccine. The mean interval from vaccination to onset was 3.9 weeks, and the incidence of preceding illness in vaccinated or unvaccinated patients was similar. Fifty-eight percent had at least one chronic disease before onset. The clinical features were similar in vaccinated and unvaccinated patients. Most deaths followed medical complications of respiratory paralysis: Fifteen had pneumonia, 29 (83%) died suuddenly, 15 had sudden arrhythmias or hypotension, and 7 had myocardial infarction or pulmonary embolus.

Address correspondence and reprint requests to Dr. Keenlyside, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226.

Accepted for publication November 30, 1979.

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