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Altered cerebral inhibition of respiratory and cardiac responses to hypercapnia in acute stroke

From the Departments of Neurology (Drs. Klassen and Lee and Ms. Heaney) and Medicine (Dr. Kronenberg), University of Minnesota, Minneapolis, MN.

Ventilatory and heart-rate responses to hypercapnia were evaluated by a CO₂ rebreathing technique in 56 patients with acute ischemic stroke and 14 normal controls. Both ventilatory and heart-rate responses were increased in patients with hemispheral lesions, but not in patients with brainstem lesions. In patients with hemispheral infarct, there was a decrease in CO₂ sensitivity 1 to 3 weeks later. Acute hemisphere lesions may result in a transient decrease of cerebral inhibition of brainstem-mediated autonomic responses to a chemical stimulus.

Address correspondence and reprint requests to Dr. Klassen, Department of Neurology, Box 295 Mayo, University of Minnesota, Minneapolis, MN 55455.

Accepted for publication December 10, 1979.

This study was supported by NINCDS Grant No. NS-03364 from the National Institutes of Health.

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