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Abnormalities of erythrocyte membranes in myotonic muscular dystrophy manifested in lipid vesicles

From the Departments of Medicine (Neurology) (Drs. Nagano and Roses) and Biochemistry (Dr. Roses), Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC.

Sodium flux was investigated in lipid vesicles derived from erythrocyte membranes of patients with myotonic dystrophy (MyD) and matched healthy controls. The lipid vesicles were prepared with phospholipid from erythrocyte membranes and "spectrin" protein preparations. Abnormal sodium permeability was demonstrated in vesicles prepared from phospholipid from the MyD patients.

Address correspondence and reprint requests to Dr. Roses, Post Office Box 2900, Duke University Medical Center, Durham, NC 27710.

Accepted for publication December 11, 1979.

This work was supported by NINCDS grants Nos. NS 13455 and NS 15060 and by a Clinical Research Grant from the Muscular Dystrophy Association.