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Stable remissions in myasthenia grams

From the Section of Neurology, (Drs. Perez, Buot, and Mercado-Danguilan) Department of Medicine, and the Department of Physiology (Drs. Bagabaldo and Renales), College of Medicine, University of the Philippines System, Manila, Philippines.

Forty-two myasthenic patients received a total of 7.6 to 130 gm of cyclophosphamide over 2 to 37 months; 33 received prednisone concomitantly. Twenty-five (6Wo) are presently asymptomatic. Seventy-four percent improved after 1 month of therapy. Fifty-eight percent of those treated for a year, 86% of those treated for 2 years, and 100% of those treated for 32 months were asymptomatic. Based on our definition of remission (asymptomatic for at least 6 months without medication), 12 of the 16 patients (75%) followed for at least 18 months were in remission. Cyclophosphamide may have more specific therapeutic effects than other immunosuppressive drugs used to treat myasthenia.

Address correspondence and reprint requests to Dr. Perez, Section of Neurology, Department of Medicine, UP-PGH, Medical Center, Taft Avenue, Manila, Phillipines.

Supported by a grant from the National Research Council of the Philippines under Research Contract IC-76.

Accepted for publication March 13, 1980.

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