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From the Departments of Neurology and Microbiology, University of Southern California, School of Medicine, Los Angeles, CA.
The pathogenesis of murine hepatitis virus, strain JHM, was studied in 6- and 12-week-old C57iBL mice. There was 100% mortality in the 6-week-old mice after intracerebral inoculation. The lesions were characterized by necrotizing encephalomyelitis, without demyelination. Intracerebral inoculation of 12-week-old animals, however, resulted in no morbidity or mortality. The 12-week-old animals showed transient virus replication in the brain, spinal cord, and liver, which was cleared by day 14. Histologic examination showed evidence of ongoing demyelination, concomitant remyelination, and hydrocephalus ex vacuo. Although viral antigen was demonstrated by immunofluorescence in the central nervous system of these animals, no infectious virus was recovered, and immunosuppression regimens did not potentiate the disease.
Address correspondence and reprint requests to Dr. Stohiman, 142 McKibben Annex, University of Southern California, 2025 Zonal Avenue, Los Angeles. CA 90033.
This work was supported by US. Public Health Service Grant No. NS 12967 and by funds from the Kroc Foundation.
Accepted for publication March 13, 1980.
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