HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Willmore, L. J. Articles by Rubin, J. J. Search for Related Content PubMed PubMed Citation Articles by Willmore, L. J. Articles by Rubin, J. J.

Antiperoxidant pretreatment and iron-induced epileptiforom discharges in the rat

EEG and histopathologic studies

From the Neurology Service, Veterans Administration Medical Center, and the Departments of Neurology and Neuroscience (Dr. Willmore), College of Medicine (Mr. Rubin), University of Florida, Gainesville, FL.

Iron causes formation of superoxide radicals resulting in peroxidation of membranous components of tissue. Hemosiderin deposition in human brain often accompanies chronic posttraumatic seizures induced by trauma. We injected an aqueous solution of iron salts, the principal metallic ion of whole blood, into rat isocortex. Serial electroencephalographic recording showed that 94% of untreated animals developed epileptiform discharges. Pretreatment with a-tocopherol and with 2 ppm selenium prevented development of iron-induced epileptiform activity in 72% of animals. Histopathologic assessment of serial sections stained with Nissl, hematoxylin and eosin, and prussian blue showed cavitation, neuronal pyknosis and loss, and astrogliosis in untreated animals. The site of iron injection in animals treated with antiperoxidants contained only an area of neuronal pyknosis. The efficacy of antioxidants in preventing development of iron-induced cavitation, gliosis, and epileptiform discharges suggests that peroxidative injury may be important in the development of experimental epilepsy induced by isocortical injection of ferrous chloride.

Address correspondence and reprint requests to Dr. Willmore, Neurology Service (127). Veterans Administration Medical Center, Gainesville, FL 32602.

This work was supported by the Research Service of the Veterans Administration and in part by a Medical Student Research Fellowship to Mr. Rubin.

Presented at the thirty-second annual meeting of the American Academy of Neurology, New Orleans, LA, April 1980.

Accepted for publication March 6, 1980.

This article has been cited by other articles:

				R Hazra, K Ray, and D Guha Inhibitory role of Acorus calamus in ferric chloride-induced epileptogenesis in rat Human and Experimental Toxicology, December 1, 2007; 26(12): 947 - 953. [Abstract] [PDF]

				U. Schweizer, L. Schomburg, and N. E. Savaskan The Neurobiology of Selenium: Lessons from Transgenic Mice J. Nutr., April 1, 2004; 134(4): 707 - 710. [Abstract] [Full Text] [PDF]

				A. Yuksel, M. Cengiz, M. Seven, and T. Ulutin Changes in the Antioxidant System in Epileptic Children Receiving Antiepileptic Drugs: Two-Year Prospective Studies J Child Neurol, August 1, 2001; 16(8): 603 - 606. [Abstract] [PDF]

				C. J. NICOL, J. ZIELENSKI, L.-C. TSUI, and P. G. WELLS An embryoprotective role for glucose-6-phosphate dehydrogenase in developmental oxidative stress and chemical teratogenesis FASEB J, January 1, 2000; 14(1): 111 - 127. [Abstract] [Full Text]

				M. V. Frantseva, J. L. P. Velazquez, and P. L. Carlen Changes in Membrane and Synaptic Properties of Thalamocortical Circuitry Caused by Hydrogen Peroxide J Neurophysiol, September 1, 1998; 80(3): 1317 - 1326. [Abstract] [Full Text] [PDF]

				N. L. Kobrinsky, J. Y. Yager, M. S. Cheang, R. W. Yatscoff, and M. Tenenbein Does Iron Deficiency Raise the Seizure Threshold? J Child Neurol, March 1, 1995; 10(2): 105 - 109. [Abstract] [PDF]