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NEUROLOGY 1981;31:70
© 1981 American Academy of Neurology

Isoelectric focusing of cerebrospinal fluid proteins in the diagnosis of multiple sclerosis

Zobeeda Z. Hosein, M.S. and Kenneth P. Johnson, M.D.

From the Neurology Service (127) Veterans Administration Medical Center, and the University of California, San Francisco, CA.

Isoelectric focusing was adapted for analysis of cerebrospinal fluid (CSF) proteins with commercially available materials. CSF from cases of multiple sclerosis or chronic neurologic infections showed abnormal populations of I&, verified by immunofixation, particularly in the high-alkaline regions (high-alkaline bands). Agarose electrophoresis showed a similar number of abnormal specimens, but patterns were more clearly defined by isoelectric focusing. Despite increased sensitivity, isoelectric focusing is too complex to replace agarose electrophoresis, but it may be useful in clinically difficult cases when agarose electrophoresis patterns are questionable.

Address correspondence and reprint requests to Ms Hosein, Neurology Service (127). Veterans Administration Medical Center, 4150 Clement St, San Francisco. CA 94121

Supported by the Veterans Administration and by Grant No RG1225 from the National Multiple Sclerosis Society and Grant No NS 14069 from the USPHS.

This study was reported in part at the thirty-first annual meeting of the American Assoclation for Clinical Chemistry, New Orlearn: LA, July 1979.

Accepted for publication February 28, 1980






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