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Gangliocytoma of third ventricle

Hyperphagia, somnolence, and dementia

Departments of Neurology and Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA

A 55-year-old man had hydrocephalus caused by a third-ventricular tumor. Mentation improved after ventricular shunting and radiation therapy. Progressive hyperphagia, obesity, memory impairment, and hypersomnolence developed 13 months later, and he died 2 years after diagnosis. At necropsy, a gangliocytonia filled the third ventricle, resulting in compression and necrosis of the ventromedial and posterior hypothalamic nuclei. Clinical manifestations were attributed to these lesions.

Address correspondence and reprint requests to Dr Hochberg, Neurology Service, Massachusetts General Hospital, Boston, MA 02114

Accepted for publication March 24, 1981

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