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Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host

The relationship to subacute sclerosing panencephalitis

Departments of Neurology (Dr. Roos), Pathology (Drs. Wollmann and Nixon), and Pediatrics (Dr. Chilcote), the University of Chicago, Pritzker School of Medicine, Chicago, IL. and the Reed Neurological Research Center, Department of Neurology (Dr. Graves), UCLA School of Medicine, Los Angeles, CA

An immunosuppressed child with acute lymphoblastic leukemia in clinical remission developed measles inclusion body encephalitis (MIBE). Although measles antigen and nonbudding measles virus nucleocap-sids were detected in brain tissue, no virus was isolated. Immune precipitation of measles virus proteins with the patient's serum showed no detectable antibody to virus M protein, a finding that has been reported in subacute sclerosing panencephalitis (SSPE). The virologic and immune precipitation studies suggest a similar virus mutation in MIBE and SSPE. The pathogenesis of the two diseases may also be similar.

Address correspondence and reprint requests to Dr Roos, University of Chicago, Pritzker School of Medicine, 950 East 59th Street, Chicago, IL 60637.

Accepted for publication February 5, 1981

Supported by a grant from the Schweppe Foundation (Dr. Roos) and the National Multiple Sclerosis Society (No. MS:RG 1130-C-16) (Dr. Roos) and NIH grant No. A1 16029 (Dr. Graves).

Portions of this paper were presented at the thirty-second annual meeting of the American Academy of Neurology, New Orleans, LA, April 1980.

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