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NEUROLOGY 1981;31:1338
© 1981 American Academy of Neurology

Physiologic basis for neuroelectric blocking activity in multiple sclerosis

C. L. Schauf, T. L. Pencek, F. A. Davis and M. W. Rooney

Department of Physiology and the Multiple Sclerosis Center, Rush University, Chicago, II.

The physiologic basis for the blocking effect of sera from patients with multiple sclerosis on isolated frog spinal cord is shown to be due to an inhibition of synaptic transmission. There are no detectable effects of blocking sera on conduction in either normal or demyelinated nerve.

Address correspondence and reprint requests to Dr. Schauf, Department of Physiology and the Multiple Sclerosis Center, Rush University, Chicago, IL 60612.

Accepted for publication January 27, 1981.

Supported by the Morris Multiple Sclerosis Research Fund and by National Multiple Sclerosis Society Grant No. RG1230A1 to C.L.S.






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