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Treatment of intractable hiccups with valproic acid

Department of Neurology, University of North Carolina, School of Medicine, Chapel Hill, NC.

Address correspondence and reprint requests to Dr. Jacobson, Section of Electroencephalography, Department of Neurology, Mayo Clinic, Rochester, MN 55901

we used valproic acid (VPA) to treat five patients with incapacitating, intractable hiccups. Symptoms were eliminated in four and markedly improved in one after other therapies (granulated sugar, carbamazepine, chlorpromazine, and nasopharyngeal stimulation) had failed. Effective peak VPA plasma levels ranged from 34 to 96 pg per milliliter.

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