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NEUROLOGY 1981;31:1480
© 1981 American Academy of Neurology

Prevalence of monoclonal protein in peripheral neuropathy

John J. Kelly, Jr., M.D., Robert A. Kyle, M.D., Peter C. O'Brien, Ph.D. and Peter J. Dyck, M.D.

Department of Neurology, the Division of Hematology and Internal Medicine, and the Section of Medical Research Statistics, Mayo Clinic and Mayo Foundation, Rochester, MN.

Address correspondence and reprint requests to Dr. Kelly, Mayo Clinic, Rochester, MN 55901.

We attempted to survey with serum protein electrophoresis all patients with peripheral neuropathy of unknown cause presenting at our institution within 1 year to determine the prevalence of monoclonal serum proteins in this group. Eighty-four percent of these patients were evaluated, and 10% of these had a monoclonal serum protein. This figure was statistically different from that obtained in two community studies in the literature. Because these patients often present difficult diagnostic problems, serum protein electrophoresis is necessary in the evaluation of cryptogenic neuropathies.




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