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Clorazepate therapy for refractory seizures

Departments of Clinical Pharmacy (Dr. Berchou) and Neurology (Dr. Rodin), Wayne State University, the Neurology Department (Dr. Rodin and Ms. Russell) and EEG (Dr. Rodin), Lafayette Clinic, and the Epilepsy Center of Michigan (Dr. Rodin).

Address correspondence and reprint requests to Dr. Berchou, Assistant Professor, Clinical Pharmacy, Wayne State University, Detroit, MI 48201.

We treated 61 patients with seizures refractory to conventional anticonvulsants by adding clorazepate to their regimen. There was some improvement of seizure control, but no overall improvement in the electroencephalogram. Improvement of seizure control was not significantly related to seizure type. No significant side effects, drug interactions, or laboratory abnormalities were noted with doses up to 3 mg per kilogram per day.