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Dopaminergic mechanism in generalized photosensitive epilepsy

Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Hospital and Institute, Montreal, Quebec, Canada.

Address correspondence and reprint requests to Dr. Quesney, Montreal Neurological Hospital and Institute, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

Apomorphine, a dopamine receptor agonist, blocked epileptic photosensitivity in patients with primary corticoreticular epilepsy. This effect was not modified by naloxone, a narcotic antagonist, suggesting that apomorphine acts on cerebral dopaminergic receptors. Apomorphine did not block spontaneous spike-and-wave discharges in patients with nonphotosensitive primary corticoreticular epilepsy. The different actions of apomorphine on spontaneous and phot-ically induced spike-and-wave activity suggest that there is a selective dopaminergic mechanism in human epileptic photosensitivity.