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Citrobacter meningitis and cerebral abscess in early infancy

Cure by moxalactam

Sections of Neurology (Dr. Levy). and Neurosurgery (Dr. Saunders), Dartmouth-Hitchcock Medical Center. Hanover, NH

Address correspondence and reprint requests to Dr. Levy, Department of Neurology, University of Rochester School of Medicine. 601 Elmwood Avenue, P.O. Box 673, Rochester, NY 14642.

A 7-week-old boy developed multiple cerebral abscesses as a complication of neonatal Citrobacter diversus meningitis. He was successfully treated medically with the experimental beta-lactam antibiotic, moxalactam. This is the first nonsurgical cure of brain abscess in early infancy. Fifty-eight percent of all previously reported cases of Citrobacter meningitis were complicated by brain abscess, mandating early, and serial computed tomography scanning in patients afflicted with the disorder. Moxalactam may become the chemotherapeutic agent of choice for the treatment of this serious neonatal infection.

This article has been cited by other articles:

				G. R. Greene, L. Heitlinger, and J. D. Madden Citrobacter Ventriculitis in a Neonate Responsive to Trimethoprim-sulfamethoxazole Clinical Pediatrics, July 1, 1983; 22(7): 515 - 517. [Abstract] [PDF]