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Fulminant amebic meningoencephalitis due to Acanthamoeba

From the Departments of Pathology (Dr. Cannon), Neurology (Dr. Grun-net), and Medicine (Dr. Kushner), University of Utah College of Medicine, Salt Lake City, UT.

A 57-year-old chronically immunosuppressed woman with systemic lupus erythematosus developed fulminant meningoencephalitis due to Acanthamoeba castellanii. Amebic trophozoites were also found in the lungs, suggesting a primary pulmonary focus of infection. This case illustrates that Acanthamoeba can cause a fulminant. rapidly fatal meningoencephalitis, as well as the previously reported chronic granulomatous meningoencephalitis.

Address correspondence and reprint requests to Dr. Cannon, Department of Pathology, University of Utah Medical Center, Salt Lake City, UT 84132.

Accepted for publication May 15, 1980.

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