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Subacute sclerosing panencephalitis

Clinical and immunologic study of 23 patients

From the Department of Neurology, Dariush-Kabir Medical School, Tehran University (Drs. Derakhshan, Lotfi, and Shakib), and the Iranian National Blood Transfusion Service (Drs. Massoud and Forcmzan-far), Tehran, Iran.

Lymphocyte subpopulations (‘active’ T cells, total T cells, and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, and C4), and immune complexes in serum and cerebrospinal fluid were studied in 23 patients with subacute sclerosing panencephalitis. The percentage of active T cells was normal. The number of patients with positive migration inhibitory response to phytohemagglutinin was lower than controls, corresponding to the diminished percentage of total T cells in patients. Clq binding (immune complex formation) was found in the sera of 10 patients.

Address correspondence and reprint requests to Dr. Derakhshan, Department of Neurology, University of Cincinnati Medical Center, 4010 Medical Sciences Building, 231 Bethesda Avenue, Cincinnati, OH 45267.

Accepted for publication May 12, 1980.

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