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Spinal fluid basic protein immunoreactive material and spinal fluid lymphocyte reactivity to basic protein

Research Center (Drs. Lisak and Zweiman), University of Pennsylvania-Wistar Instititute, Philadelphia, PA, and the Department of Neurology (Dr. Whitaker), University of Tennessee, Veterans Administration Medical Center, Memphis, TN.

Levels of cerebrospinal fluid (CSF) basic protein (BPI immunoreactive material and CSF lymphocyte in vitro reactivity to BP were determined in patients with demyelinating and other inflammatory diseases of the nervous system. Elevated levels of BP and enhanced in vitro reactivity were observed, but there was no correlation between the magnitude of the in vitro response and the amount of BP-like material in CSF.

Address correspondence and reprint requests to Dr. Lisak, Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Supported in part by USPHS Grant No. NS 11037-07, Medical Research of the Veterans Administration, and Grants Nos. RG 894-B-Z and 1111-A-3 from the Multiple Sclerosis Society.

Accepted for publication May 8, 1980.