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NEUROLOGY 1981;31:220
© 1981 American Academy of Neurology

No direct correlation between serum antiacetylcholine receptor antibody levels and clinical state of individual patients with myasthenia gravis

Allen D. Roses, M.D., C. Warren Olanow, M.D., Mildred W. McAdams, B.S. and Russell J. M. Lane, M.B., B.S.

From the Howard Hughes Medical Institute (Dr. Roses), the Departments of Medicine (Neurology) (Drs. Roses, Olanow, and Lane, and Ms. McAdams) and Biochemistry (Dr. Roses), Duke University Medical Center, Durham, NC.

Serum acetylcholine receptor antibodies were measured serially in myasthenia gravis patients before and after early extended thymectomy; they received no medication postoperatively. Clinical improvement occurred with little or no change in antibody level. After plasmapheresis without immunosuppressive drug therapy, we also found clinical improvement without decrease in serum antibody level.

Address correspondence and reprint requests to Dr. Roses, Box 2900, Duke University Medical Center, Durham, NC 27710.

Dr. Russell Lane was a Clinical Fellow of the Muscular Dystrophy Association of America. This work was supported in part by grants from the Muscular Dystrophy Association of America and the National Multiple Sclerosis Society.

Accepted for publication April 1, 1980




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W W Y Wong and R J M Lane
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J. Neurol. Neurosurg. Psychiatry, September 1, 2004; 75(9): 1363 - 1363.
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