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Pemoline-induced chorea

From the Department of Neurological Sciences, Rush-Presbyterian St. Lukes Medical Center, Chicago, IL.

Acute chorea in a child followed ingestion of pemoline mesylate. In guinea pigs, in an experimental model of chorea, chronic administration of pemoline induced behavioral supersensitivity to other dopaminergic agonists. Pemoline is similar to both d-amphetamine and methylphenidate in altering central dopaminergic sensitivity, and may cause chorea by similar mechanisms. Chronic pemoline therapy may offer no significant advantage over therapy with other indirect dopamine agonists.

Address correspondence and reprint requests to Dr. Nausieda, 1725 W. Harrison, Suite 915, Chicago, IL 60612.

This material was presented in part at the thirty-second annual meeting of the American Academy of Neurology, New Orleans, LA, May 1980.

This research was supported by funds from the United Parkinson Foundation and the Boothroyd Foundation, Chicago, IL.

Accepted for publication June 12, 1980.