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NEUROLOGY 1981;31:282
© 1981 American Academy of Neurology

Myasthenia gravis

Passive transfer to mice of antibody to human and mouse acetylcholine receptor

Kenichiro Oda, Susumu Korenaga and Yushi Ito

From the Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Mice were given intraperitoneal injections of serum from three patients with myasthenia gravis who had different titers of antibody against mouse acetylcholine receptor (AChR). Almost all mice treated with a high titer of serum antigens showed generalized paralysis, reduced amplitudes of miniature endplate potential (MEPP), or reduced numbers of AChRs. The effects were less marked in serum with lower titers of antibody to mouse AChR, and there was no relation of the severity of effects to the titer of antibody to human AChR.

Address correspondence and reprint requests to Dr Ito, Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka 812 Japan

Accepted for publication May 29, 1980.






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