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Antifibrinolytic therapy in subarachnoid hemorrhage caused by ruptured intracranial aneurysm

From the University of Minnesota, Minneapolis, and St Paul-Ramsey Medical Center, St Paul, MN.

There are 25 published studies on the treatment with antifibrinolytic agents of subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysm. Twelve of these studies were uncontrolled and, except for one, all reported reduced incidence of rebleeding. Of 13 controlled studies, 9 were randomized, and 3 were also double-blind. In 7, reported decrease in rebleeding was reported, but only 4 showed decreased mortality. Three studies showed no effect, and three reported a higher incidence of rebleeding in treated patients. Discrepancies may be due to the multiple clinical variables of SAH and to flaws in methodology; nevertheless, the data fail to demonstrate that antifibrinolytic therapy alters the natural history of the disease.

Address correspondence and reprint requests to Dr Ramirez-Lassepas, Department of Neurology, St Paul-Ramsey Medical Center, 640 Jackson Street, St Paul, MN 55101

This work was supported in part by the by the St Paul-Ramsey Hospital Medical Education and Research Foundation

Accepted for publication June 2, 1980.

This article has been cited by other articles:

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				H. P. Adams Jr Antifibrinolytics in Aneurysmal Subarachnoid Hemorrhage: Do They Have a Role? Maybe Arch Neurol, January 1, 1987; 44(1): 114 - 115. [Abstract] [PDF]

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