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New form of familial Parkinson-dementia syndrome

Clinical and pathologic findings

Departments of Neurology and Pathology, University uf Michigan, Ann Arbor, MI.

We studied a family in which three siblings had a syndrome characterized by parkinsonism features, mental deterioration, pyramidal signs, and abnormal eye movements beginning in the third decade. The pathology resembled that of progressive supranuclear palsy or the Parkinson-dementia complex of Guam, but these were excluded by the clinical presentation. This syndrome appears to be a new entity.

Address correspondence and reprint requests to Dr. Mata. Neurology Service (127), Veterans Administration Medical Center, Ann Arbor, MI 48105.

Accepted for publication March 7, 1983.

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