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Myoclonic, atonic, and absence seizures following institution of carbamazepine therapy in children

Departments of Neurology and Pediatrics. UCLA School of Medicine, Los Angeles, CA.

Five children, aged 3 to 11 years, treated with carbamazepine for epilepsy, had an acute aberrant reaction characterized by the onset of myoclonic, atypical absence and/or atonic (minor motor) seizures within a few days. When the carbamazepine was discontinued, two of the children returned to their former state very quickly, two had the minor motor seizures resolve in 3 and 6 months, and one had the seizures persist. The child in whom the seizures persisted was later found to have ceroid lipofuscinosis. The other children are doing well on other anticonvulsants.

Address correspondence and reprint requests to Dr. Shields, Chief, Division of Pediatric Neurology, UCLA School of Medicine, Los Angeles. CA 90024.

Supported in part by the Department of Health and Human Services contract No. N01-NS-0-2332.

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