HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Young, A. B. Articles by Gilman, S. Search for Related Content PubMed PubMed Citation Articles by Young, A. B. Articles by Gilman, S.

Glutamate or aspartate as a possible neurotransmitter of cerebral corticofugal fibers in the monkey

Department of Neurology, University of Michigan, Ann Arbor, MI.

We measured high affinity glutamate uptake in subcortical projection sites of monkey (Macaca fascicularis) 8 weeks after unilateral ablation of Brodmann's areas 4 and 6. Uptake decreased ipsilateral to the lesion in ventrolateral nucleus of thalamus, caudate nucleus, and pons. Uptake also decreased contralateral to the lesion in cervical and lumbar spinal cord. These results suggest that L-glutamate (or possibly L-aspartate) is a neurotransmitter of corticofugal fibers in primate.

Address correspondence and reprint requests to Dr. Young, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48109.

Supported by USPHS grants Nos. NS 15655, NS 00420, NS 00464, and NS 15140 and the United Cerebral Palsy Research and Educational Foundation (UCP R 291 and R 305).

Accepted for publication February 23, 1983.

This article has been cited by other articles:

				A. B. Young Four Decades of Neurodegenerative Disease Research: How Far We Have Come! J. Neurosci., October 14, 2009; 29(41): 12722 - 12728. [Full Text] [PDF]

				A. K. Afifi Topical Review: Basal Ganglia: Functional Anatomy and Physiology. Part 1 J Child Neurol, July 1, 1994; 9(3): 249 - 260. [Abstract] [PDF]

				J. T. Greenamyre The Role of Glutamate in Neurotransmission and in Neurologic Disease Arch Neurol, October 1, 1986; 43(10): 1058 - 1063. [Abstract] [PDF]

				J. W. Cochran and A. H. Cochran Monosodium Glutamania: The Chinese Restaurant Syndrome Revisited JAMA, August 17, 1984; 252(7): 899 - 899. [Abstract] [PDF]