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Interictal conduction slowing in muscle fibers in hypokalemic periodic paralysis

1st (Dr. Troni) and 2nd (Drs. Doriguzzi and Mongini) Neurological Clinics, University Medical School, Torino, Italy.

Conduction velocity in muscle fibers of the short head of biceps brachii was reduced between attacks in all the affected members of a family suffering from hypokalemic periodic paralysis. This finding represents a further evidence of a primary alteration of sarcolemmal function in this disease. Interictal conduction slowing in muscle fibers is consistent with the prevailing pathophysiologic hypothesis, which considers an increased membrane permeability to sodium ions as the fundamental defect underlying all forms of familial periodic paralysis.

Address correspondence and reprint requests to Dr. Troni, Clinica Neurologica dell'Università, Via Cherasco 15, 10126 Torino, Italy.

Presented in part at the fifth International Congress on Neuromuscular Diseases, Marseilles, France, September 1982.

Accepted for publication February 23, 1983.

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