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Newborn infants to myasthenic mothers

AL clinical study and an investigation of acetylcholine receptor antibodiesin 17 children

Department of Clinical Chemistry, Huddinge University Hospital, and the Department of Neurology, Uppsala University Hospital, Sweden.

We studied 17 children born to 15 myasthenic mothers; 2 of the infants had neonatal myasthenia pravis. Pyridostigmine was transferred to the child and accumulated in the amniotic fluid. Sixteen children had receptor antibodies at birth. In the affected infants, the half-life of the receptor antibody concentration was longer than it was in the others. Using an anti-idiotypic antibody, we found marked differences between the idiotypes in the mother and in affected children. Transient synthesis of receptor antibodies in the child seems to be a factor in the pathogenesis of nieonatal myasthenia gravis.

Address correspondence and reprint requests to Dr. Lefvert, Department of Clinical Chemistry, Huddinge University Hospital, S-141 86, Huddinge, Sweden.

This investigation was supported by grants from the Swedish Medical Research Council and the Swedish Society of Medical Sciences.

Accepted for publication June 21, 1982.

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