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NEUROLOGY 1983;33:391
© 1983 American Academy of Neurology

Cerebral blood flow and cerebrovascular CO2 reactivity in stroke-age normal controls

Stephen M. Davis, FRACP, Robert H. Ackerman, MD, John A. Correia, PhD, Nathaniel M. Alpert, PhD, Jen Chang, MS, Ferdinando Buonanno, MD, Roger E. Kelley, MD, Bernard Rosner, PhD and Juan M. Taveras, MD

From the Stroke Center, the Cerebral Blood Flow and Carotid Evaluation Laboratories, the Neurology Service (Drs. Ackerman, Buonanno, Davis, and Kelley) and the Department of Radiology (Drs. Ackerman, Alpert, Buonanno, Correia, Davis, Kelley, and Taveras, and Mr. Changj, Massachusetts General Hospital, Boston; The Department of Medicine (Dr. Rosner), Brigham and Women's Hospital, Boston; and the Departments of Radiology, Neurology, and Preventive Medicine and Clinical Epidemiology, Harvard Medical School, Boston, MA.

We used the noninvasive 133-xenon inhalation technique to determine cerebral hemodynamics in 55 normal volunteers aged 18 to 88. Values for cerebral blood flow and cerebrovascular CO2 reactivity in fastclearing tissue (flow gray) and slow-clearing tissue (flow white) were examined as functions of age and in relation to hematocrit, blood pressure, and evidence of extracranial vascular disease. Flow gray declined linearly with age, but no corresponding change was found in flow white or in CO, reactivity. The data suggest that the progressive fall in flow gray is due to a physiologic aging process.

Address correspondence and reprint requests to Dr. Ackerman, Director, Cerebral Blood Flow and Carotid Evaluation Laboratories. Massachusetts General Hospital, Boston, MA 02114.

This work is supported in part by grant No. NS 10828 from the National Institutes of Health.

Presented in part at the thirty-third annual meeting of the American Academy of Neurology, Toronto, Ontario, April 1981.

Accepted for publication July 23, 1982




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