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NEUROLOGY 1983;33:510
© 1983 American Academy of Neurology

The effect of chronic anticonvulsant therapy on serum lipids and lipoproteins in epileptic children

Dov Heldenberg, MD, Shaul Harel, MD, Moshe Holtzman, MD, Ora Levtow, MSc and Israel Tamir, MD

From the Departments of Pediatrics (Drs. Heldenberg and Tamir and Ms. Levtow) and Neurology (Drs. Hare1 and Holtzman), "Rokach" Hospital, the University of Tel-Aviv, Sackler School of Medicine, Tel-Aviv, Israel.

We measured serum lipids and lipoproteins in 33 epileptic children who were treated with phenobarbital, valproate, and carbamazepine. High-density lipoprotein cholesterol (HDL-c) was significantly higher in the epileptic children than in two control groups: healthy nonepileptic children, and epileptic children before starting anticonvulsant therapy. Our findings indicate that anticonvulsant drugs should be added to the list of substances that affect serum HDL-c.

Address correspondence and reprint requests to Dr. Heldenberg, Department of Pediatrics, "Hillel-Jaffe" Hadera, Israel.

Accepted for publication July 26, 1982




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