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NEUROLOGY 1983;33:737
© 1983 American Academy of Neurology

Human fetal muscle-specific antigen is restricted to regenerating myofibers in diseased adult muscle

Orest Hurko, MD and Frank S. Walsh, PhD

Muscular Dystrophy Laboratories, Institute of Neurology, London, England.

A monoclonal antibody, 5.1H11, directed against human fetal muscle and myogenic cells in tissue culture, was used for immunofluorescence analysis of frozen sections of muscle biopsies from 24 patients with different diseases of muscle. The staining pattern was highly specific; detectable levels of the 5.1H11 antigen were restricted to regenerating myofibers as assessed by comparison with serial sections stained with hematoxylineosin. There was no appreciable staining of intrafusal, normal adult extra fusal, denervated, degenerating, or necrotic muscle fibers. Thus, the 5.1H11 antibody allows unambiguous identification of regenerating myofibers in biopsy specimens.

Address correspondence and reprint requests to Dr. Walsh, Muscular Dystrophy Labs, Institute of Neurology, Queen Square, London WC1N 3BG, England.

This work was supported by grants from the Muscular Dystrophy Group of Great Britain. Orest Hurko is the William O. Moseley, Jr., Travelling Fellow of Harvard University.

Accepted for publication September 20, 1982.




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