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NEUROLOGY 1983;33:786
© 1983 American Academy of Neurology

Silicon as a potential uremic neurotoxin

Trace element analysis in patients with renal failure Charles O. Hershey, MD, Edmond S. Ricanati, MD, Linda A. Hershey, MD, PhD, Arthur W. Varnes, PhD, Patrick J.M. Lavin, MD and William H. Strain, PhD

Departments of Medicine (Drs. CO Hershey and Ricanati), Neurology (Drs. LA Hershey and Lavin) and Surgery (Dr. Strain), Case Western Reserve University School of Medicine and Sohio Research and Development Center (Dr. Varnes), Cleveland, OH.

we analyzed multiple trace elements in tap water, dialysis fluids, and CSF of patients on dialysis and with chronic renal insufficiency. Before placement of a deionizer in the dialysis unit, we found elevated levels of aluminum, barium, copper, silicon, and zinc in tap water and dialysis fluids. These were corrected by the deionizer. CSF silicon content was increased in patients with chronic renal insufficiency and on dialysis; CSF aluminum, barium, copper, and zinc were normal.

Address correspondence and reprint requests to Dr. C. O. Hershey, Department of Medicine, Cleveland Metropolitan General Hospital, 3395 Scranton Road, Cleveland, OH 44109.

Presented in part at the thirty-fourth annual meeting of the American Academy of Neurology, Washington, DC, April 1982.

Accepted for publication September 20, 1982.




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