HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Obeso, J. A. Articles by Marsden, C. D. Search for Related Content PubMed PubMed Citation Articles by Obeso, J. A. Articles by Marsden, C. D.

Myoclonic dystonia

University Department of Neurology, Institute of Psychiatry and King's College Hospital Medical School, London, England.

We studied 14 patients who had a combination of idiopathic torsion dystonia and myoclonic jerks. In many cases, the same muscles were involved in both the myoclonus and the dystonia. This made observation of the crucial dystonic postures difficult and led to misdiagnosis of other dyskinesias. The jerks usually were brief (50 to 200 msec) and occurred irregularly, often showing cocontraction in antagonist muscles. Frequently, they were superimposed upon sustained dystonic contractions in the same or distant muscles. We found no time-locked EEG event before the jerks. The myoclonus probably arises from a subcortical focus, and the visible jerks probably are part of the spectrum of involuntary movements that accompany torsion dystonia.

Address correspondence and reprint requests to Dr. Marsden, University Department of Neurology, Institute of Psychiatry and King's College Hospital Medical School, Denmark Hill, London SE5 8AF, England.

JAO and JCR were supported by the British MRC, and AEL by the Canadian MRC and an H.K. Detweiler Travel Fellowship.

Accepted for publication November 11, 1982.

This article has been cited by other articles:

				E. Roze, E. Apartis, F. Clot, N. Dorison, S. Thobois, L. Guyant-Marechal, C. Tranchant, P. Damier, D. Doummar, N. Bahi-Buisson, et al. Myoclonus-dystonia: Clinical and electrophysiologic pattern related to SGCE mutations Neurology, March 25, 2008; 70(13): 1010 - 1016. [Abstract] [Full Text] [PDF]

				C M Magarinos-Ascone, I Regidor, J C Martinez-Castrillo, M Gomez-Galan, and R Figueiras-Mendez Pallidal stimulation relieves myoclonus-dystonia syndrome J. Neurol. Neurosurg. Psychiatry, July 1, 2005; 76(7): 989 - 991. [Abstract] [Full Text] [PDF]

				E. M. Valente, M. J. Edwards, P. Mir, A. DiGiorgio, S. Salvi, M. Davis, N. Russo, M. Bozi, H. -T. Kim, G. Pennisi, et al. The epsilon-sarcoglycan gene in myoclonic syndromes Neurology, February 22, 2005; 64(4): 737 - 739. [Abstract] [Full Text] [PDF]

				E. M.J. Foncke, C. Klein, J. H.T.M. Koelman, P. L. Kramer, K. Schilling, B. Muller, J. Garrels, P. de Carvalho Aguiar, L. Liu, A. de Froe, et al. Hereditary myoclonus-dystonia associated with epilepsy Neurology, June 24, 2003; 60(12): 1988 - 1990. [Abstract] [Full Text] [PDF]

				C. Klein, M. F. Brin, P. Kramer, M. Sena-Esteves, D. de Leon, D. Doheny, S. Bressman, S. Fahn, X. O. Breakefield, and L. J. Ozelius Association of a missense change in the D2 dopamine receptor with myoclonus dystonia PNAS, April 27, 1999; 96(9): 5173 - 5176. [Abstract] [Full Text] [PDF]

				P Krystkowiak, P Martinat, L Defebvre, J P Pruvo, D Leys, and A Destée Dystonia after striatopallidal and thalamic stroke: clinicoradiological correlations and pathophysiological mechanisms J. Neurol. Neurosurg. Psychiatry, November 1, 1998; 65(5): 703 - 708. [Abstract] [Full Text]

				M. R. Pranzatelli Topical Review: Antidyskinetic Drug Therapy for Pediatric Movement Disorders J Child Neurol, September 1, 1996; 11(5): 355 - 369. [Abstract] [PDF]

				I. N Back Terminal restlessness in patients with advanced malignant disease Palliative Medicine, October 1, 1992; 6(4): 293 - 298. [Abstract] [PDF]