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NEUROLOGY 1983;33:831
© 1983 American Academy of Neurology

Herpes simplex encephalitis

Analysis of a cluster of cases by restriction endonuclease mapping of virus isolates

Marie L. Landry, MD, Naomi Berkovits, BS, Wilma P. Summers, PhD, John Booss, MD, G. D. Hsiung, PhD and William C. Summers, MD, PhD

Departments of Laboratory Medicine (Drs. Landry, Booss, and Hsiung), Medicine (Dr. Landry), Therapeutic Radiology (Drs. Landry, W.P. Summers, and W.C. Summers), Molecular Biophysics and Biochemistry (N. Berkovitz and Dr Summers), Human Genetics (Dr. W.C. Summers), and Neurology (Dr. Booss), Yale University School of Medicine, New Haven, CT, and Virology Laboratory (Dr. Hsiung), Veterans Administration Medical Center, West Haven, CT.

In December 1979, there were three deaths from culture-proven herpes encephalitis in 3 weeks in the New Haven area, and a nurse caring for one of these patients developed a herpetic lesion on her nose. The three brain isolates, the isolate from the nurse, and several epidemiologically unrelated strains were analyzed by restriction endonuclease mapping. All were determined to be distinct strains of herpes simplex virus. The possibility that a single strain of virus caused this cluster of cases was therefore examined directly and disproved.

Address correspondence and reprint requests to Dr. Landry, Radiobiology Section, HRT 366, Yale University School of Medicine, 333 Cedar Street, New Haven. CT 06510.

This study was supported in part by grant Nos. CA 06519 and CA 16038 from the National Cancer Institute, by Public Health Service Research training grant No. T-32-A1 07018 from the Institute of Allergy and Infectious Disease, and by the Veterans Administration Research Fund.

Accepted for publication November 24, 1982.






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