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NEUROLOGY 1983;33:841
© 1983 American Academy of Neurology

Sympathetic postganglionic unmyelinated axons in the rat peripheral nervous system

David Chad, MD, FRCP (C), Walter G. Bradley, DM, FRCP, Chaudri Rasool, PhD, Paul Good, BS, Seymour Reichlin, MD, PhD and Justin Zivin, MD, PhD

Departments of Neurology (Drs. Chad, Bradley, and Rasool, and Mr. Good) and Medicine (Dr. Reichlin) of the Tufts-New England Medical Center, Boston, MA, and the Department of Neurology (Dr. Zivin) at the University of Massachusetts, Worcester, MA.

We determined the contribution made to the unmyelinated axon population of the rat peripheral nervous system by sympathetic paravertebral ganglion cells. Sympathectomy, achieved by administration of guanethidine to neonatal rats, led to atrophy of the sympathetic paravertebral ganglion chain, a 95% decrease in peripheral nerve norepinephrine, and loss of 20 to 26% of the unmyelinated axons in a cutaneous nerve (sural), a muscular nerve (nerve to soleus), and a mixed nerve (sciatic). These data indicate that up to a quarter of the total population of peripheral nerve unmyelinated axons are sympathetic ganglia-derived.

Address correspondence and reprint requests to Dr. Chad, Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01605.

This work was supported in part by a grant from the MDA. Dr. Chad was a Research Fellow of the MDA.

Portions of this paper were presented at the thirty-fourth annual meeting of the American Academy of Neurology, Washington, DC, April 1982.

Accepted for publication November 1, 1982.






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