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Oxidative metabolic responses during recurrent seizures are independent of convulsant, anesthetic, or species

Department of Physiology (Dr. Kreisman), Tulane University School of Medicine, New Orleans, LA, and the Departments of Neurology and Physiology/Biophysics (Drs. Rosenthal, Sick, and LaManna), University of Miami School of Medicine, Miami, FL.

A transition from sufficient to insufficient cerebral oxygenation has been reported during recurrent seizures, but it was unknown whether this phenomenon was limited to particular species, anesthetics, or convulsant agents. Focal measurements were made of cortical Po₂ and redox changes of cytochrome a,a₃ in rats and cats anesthetized with sodium pentobarbital, nitrous oxide, or ketamine, or decerebrated. Seizures were induced with pentylenetetrazol, bicuculline, or electroconvulsive shock. Transition from oxygen sufficiency to insufficiency always occurred in association with inadequate vascular responses, regardless of experimental conditions. These results indicate that transition is a general characteristic of experimental status epilepticus.

Address correspondence and reprint requests to Dr. Kreisman, Department of Physiology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112.

This investigation was supported by grants from the Epilepsy Foundation of America, American Heart Association of Louisiana, Inc., and an investigation Biomedical Research Support Grant (Dr. Kreisman); NIH grants Nos. NS 14319 and NS 14325 (Dr. Rosenthal); NIH postdoctoral fellowship No. NS 06300 (Dr. Sick); and RCDA No. NS 00399 (Dr. LaManna).

Accepted for publication October 19, 1982.

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