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NEUROLOGY 1983;33:885
© 1983 American Academy of Neurology

Subacute sclerosing panencephalitis

An immune complex disease?

Ana Sotrel, MD, Seymour Rosen, MD, Michael Ronthal, MD and David B. Ross, MD

Department of Pathology (Neuropathology) (Dr. Sotrel), Children's Hospital Medical Center, Boston, MA, the Departments of Pathology (Drs. Sotrel and Rosen) and Neurology (Drs. Ronthal and Ross) Beth Israel Hospital—Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA, and the Departments of Pathology and Neurology, Harvard Medical School, Boston, MA.

Vascular osmiophilic deposits of entangled tubular profiles were demonstrated by electron-microscopy in the cerebral tissue of a patient with subacute sclerosing panencephalitis. Measles viral antigen, IgG, IgM, and C3 were found in the same distribution, indicating that the deposits represent immune complexes. To our knowledge, this is the first demonstration of immune complexes in the vessels of the central nervous system.

Address correspondence and reprint requests to Dr. Sotrel, Department of Neuropathology, Children's Hospital Medical Center, 300 Longwood Avenue, Boston, MA 02115.

Accepted for publication October 25, 1982.






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