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A double-blind study comparing carbamazepine with phenytoin as initial seizure therapy in adults

Department of Neurology (Drs. Ramsay and Berger), VA Medical Center and University of Miami, the Department of Neurology (Dr. Wilder), VA Medical Center & University of Florida, and the Department of Neurology (Dr. Bruni), University of Toronto, Ontario, Canada.

Carbamazepine was compared with phenytoin in a double-blind study. Of 87 patients, data on 70 patients were complete and used for analysis. Thirty-five patients were treated with each drug. The incidence of major side effects, minor side effects, and complete control (85%) was the same in both groups. A mild but significant elevation of WBC count was found before initiation of drug treatment in the patients presenting with generalized convulsive seizures. Sporadically, elevations in SGOT and LDH were seen; WBC counts below 4,000 were reported, but these were not clinically significant.

Address correspondence and reprint requests to Dr. Ramsay, Department of Neurology, Veterans Administration Medical Center, 1601 NW 12th Avenue, Miami, FL 33125.

The work was supported in part by the Southern Foundation for Brain Research.

Accepted for publication October 11, 1982.

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