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NEUROLOGY 1984;34:534
© 1984 American Academy of Neurology

Distribution of freeze fracture particle sizes in Duchenne muscle plasma membrane

Kenneth H. Fischbeck, MD, Eduardo Bonilla, MD and Donald L. Schotland, MD

From the Department of Neurology, University of Pennsylvania, Philadelphia, PA.

We studied the distribution of freeze-fracture intramembranous particle (IMP) sizes in Duchenne muscie biopsies and controls. We found that the previously reported decrease in muscle plasma membrane particle density in Duchenne includes a variety of different IMPs, but does not preferentially involve IMPs of any one size.

Address correspondence and reprint requests to Dr. Fischbeck, Department of Neurology, G1, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104.

Supported by a center grant from the Muscular Dystrophy Association and by NIH grants 5 KO7 NS00695-02 and NS08075.

Presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego, CA, April 1983.

Accepted for publication July 21, 1983.







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