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From the Departments of Neurology and Neurological Surgery (Neurology) (Drs. Berg, Danziger, Coben, and Hughes), Radiology (Dr. Gado), and Psychiatry (Dr. Knesevich), Washington University School of Medicine, and the Department of Psychology (Drs. Storandt and Botwinick), Washington University, St. Louis, MO.
Forty-three subjects with mild senile dementia of the Alzheimer type, diagnosed and staged by clinical research criteria, were studied with clinical, psychometric, EEG, visual evoked potential, and CT measures. During the 12 months following entry into the study, 21 subjects progressed to moderate or severe dementia, 21 remained mild, and one was lost to follow-up. Many of the clinical and psychometric measures of impairment were predictive of the progression to moderate or severe dementia. Electrophysiologic and CT measures were not. In a discriminant function analysis, the scores on two measures (the digit symbol subtest of the Wechsler Adult Intelligence Scale and an Aphasia Battery) correctly predicted the stage of dementia 1 year later in 95% of the subjects.
Address correspondence and reprint requests to Dr. Coben, Department of Neurology and Neurological Surgery, Box 8111, Washington University School of Medicine. 660 South Euclid Avenue. St. Louis. MO 63110.
Supported in part by grants from the National Institute of Mental Health (MH31054) and from the Retirement Research Foundation.
Accepted for publication August 9, 1983.
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