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NEUROLOGY 1984;34:620
© 1984 American Academy of Neurology

Effects of ethosuxirnide and tetramethylsuccinimide on cultured cortical neurons

Deborah M. Barnes, PhD and Marc A. Dichter, MD, PhD

From the Department of Neuroscience. The Children's Hospital (Drs. Barnes and Dichter), the Department of Neuropathology. Harvard Medical School (Dr. Barnes), and the Department of Neurology, Beth Israel Hospital (Dr. Dichter). Boston. MA.

In cultured cortical neurons, ethosuximide (ESM) had unexpected actions for an antiepileptic drug; it slightly diminished the effects of inhibitory neurotransmitters, GABA, and glycine. ESM had no direct membrane effects, did not change action potential characteristics or alter spontaneous activity, and did not reverse the effects of convulsants that are GABA antagonists. The structurally related convulsant tetramethylsuccinimide (TMSM) reduced the amplitude of GABA-mediated inhibitory postsynaptic potentials and antagonized responses to applied GABA, effects not reversed by ESM. The convulsant effects of TMSM include a blockade of postsynaptic GABA actions, but the antiepileptic effects of ESM are not due to an enhancement of GABA-mediated inhibition.

Address correspondence and reprint requests to Dr. Dichter. Dept. of Neuroscience G-4. The Children's Hospital. 300 Longwood Ave., Boston. MA 02115.

This work was supported by the National Institutes (if Health Grants NS06869. NS15362, and The Children's Hospital Medical Center Mental Retardation Center Cure Grant HDO6276.

Accepted for publication September 19, 1983.






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