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Dissociated patterns of nocturnal prolactin, cortisol, and growth hormone secretion after stroke

From the Neurology Service (Dr. Culebras) and the Medical Service (Dr. Miller), Veterans Administration Medical Center and the Departments of Neurology and Medicine, SUNY Upstate Medical Center, Syracuse, NY.

The secretory activity of the hypothalamic-pituitary axis is influenced by suprahypothalamic regulatory mechanisms. To evaluate the effect of brain lesions on hormonal patterns, we investigated eight patients convalescing from hemispheric stroke and five sex- and age-matched healthy volunteers. Studies were conducted during two consecutive nights with continuous polygraphic recording and sequential blood sampling. Nocturnal plasma hormone measurements showed a normal rhythm of cortisol (a marker of ACTH), elevated prolactin concentrations (p &;t' 0.05) and low growth hormone values (p < 0.05). The study suggests that major suprahypothalamic lesions influence hypothalamic function so as to facilitate prolactin secretion and inhibit growth hormone release. They have no effect on the more basic pattern of ACTH-cortisol secretion, however.

Address correspondence and reprint requests to Dr. Culebras, Neurology Service, Veterans Administration Medical Center, 800 Irving Avenue, Syracuse, NY 13210.

Supported by Veterans Administration research funds.

Presented at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego, CA, April, 1983.

Accepted for publication September 7, 1983.

This article has been cited by other articles:

				S Schwarz, S Schwab, K Klinga, C Maser-Gluth, and M Bettendorf Neuroendocrine changes in patients with acute space occupying ischaemic stroke J. Neurol. Neurosurg. Psychiatry, June 1, 2003; 74(6): 725 - 727. [Abstract] [Full Text] [PDF]