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From the Department of Neurology (Drs. Mayeux. Stern, and Cote). Rehabilitation Medicine (Dr. Cote). and Psychiatry (Dr. Williams), College of Physicians and Surgeons. Columbia University. New York, NY.
Depression is a common symptom inpatients with Parkinson's disease. It is not related to the severity of the motor symptoms or changes in dopamine metabolism and does not improve on treatment with dopamine agonists. Alterations in serotonin metabolism are found in primary (endogenous) depression. The brain content of serotonin in Parkinson's disease is also reduced, but this has not been related to any manifestation of the disorder. We found that the CSF content of the major metabolite of serotonin, 5-hydroxyindoleacetic acid, was lower in depressed than in nondepressed parkinsonians. The data suggest that the alterations in serotonin metabolism in Parkinson's disease identify a subgroup of patients who are prone to depression.
Address correspondence and reprint requests to Dr. Mayeux. Neurological Institute, 710 West 168th Street, New York, NY 10032.
This work was supported by an NIH award AG02802 (Dr. Mayeux). by the Parkinson's Disease Foundation (Dr. Stern), and by research funds from the Department of Rehabilitation Medicine (Dr. Cote). This work was completed in a Clinical Research Center in the Presbyterian Hospital in the City of New York, funded by an NIH award (RR00645).
Presented in part at the 35th annual meeting of the American Academy of Neurology in San Diego. CA, April 1983.
Accepted for publication September 9, 1983.
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