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Biochemistry of the hypothalamus in Parkinson's disease

From the Laboratoire de Médecine Experimentale (Drs. Javoy-Agid, Ruberg, and Agid), Laboratoire de Biochimie Médicale (Drs. Taquet, Studler, and Cesselin), CHU Pitié-Salpêtière; Centre de Rechercbes Endocrinologiques Drs. Pique and Bertagna), Hôspital Cochin; and Unité 159 de l'INSERM (Dr. Epelbaum) Paris, France.

We assayed the content of neurotransmitters (or their synthesizing enzymes) and neuropeptides in the hypothalamus of control and parkinsonian brains post mortem. Only dopamine oncentrations were lower than normal in Parkinson's disease, suggesting that deficiency in hypothalamic dopamine transmission may play a role in the autonomic and endocrine abnormalities of this disorder.

Address correspondence and reprint requests to Dr. Javoy-Agid, Laboratoire de Médecine Expérimentale, CHU Pitié-Salpêtrière, 91, Bd de l'Hôpital, 75634 Paris CEDEX 13, France.

Partlysupported by INSERM (PRC Sante Mentale et Cerveau) and CNRS.

Accepted for publication August 9, 1983.

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