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Histologic evidence for death of cortical neurons after spinal cord transaction

From the Neurology Research Laboratories, VA Medical Center, and Department of Neurosciences, University of California, San Diego, CA.

Dying cortical neurons, identified by standard histologic criteria, were observed in the rat sensory/motor cortex after spinal cord transection. The peak incidence of these changes was 10 weeks after injury. At that time, spinal-cord-injured animals showed 10 times as many abnormal cells as were found in matched controls (p 0.05). Dying cells were found in the same anatomic location as corticospinal neurons axotomized by the experimental injury, and at the expected time after injury. The survival of corticospinal neurons in these young adult rats may be dependent on obtaining a crucial input from an appropriate target cell (neuron).

Address correspondence and reprint requests to Dr. Feringa, Chief, Neurology Service (127), VA Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161.

This research was supported by the VA Research Service.

Presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego, CA, April 1983.

Accepted for publication December 6, 1983.

This article has been cited by other articles:

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