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From the Department of Neurology, University of Turku, Turku, Finland.
The occurrence and type of extrapyramidal signs were investigated in 143 patients with dementia of the Alzheimer type. Only 8% of the patients were free of extrapyramidal signs. The most common type of extrapyramidal involvement was a rigid, hypokinetic, and hypomimic pattern. Resting tremor was rarely encountered. Dyskinetic signs, mostly orofacial, were seen in 17%. These observations suggest that in most patients with advanced Alzheimer's disease, there is a striatal dopaminergic hypofunction, appearing clinically as hypokinesia and rigidity. However, some patients exhibit predominantly dyskinetic signs, implying more complex basal ganglia dysfunction.
Address correspondence and reprint requests to Dr. Mölsä, Department of Neurology, University of Turku, SF-20520 Turku 52, Finland.
This study was supported by the Sigrid Jusélius Foundation, Finland.
Accepted for publication December 8, 1983.
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