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© 1984 American Academy of Neurology The fate of severed corticospinal axonsFrom the Departments of Neurology (Dr. Fishman) and Anatomy and Cell Biology (Dr. Kelly), College of Physicians and Surgeons, Columbia University, New York, NY. The potential for regeneration of severed corticospinal axons was examined by labeling these axons with horseradish peroxidase following thoracic spinal cord transections in mice. Shortly after severance, the proximal ends of corticospinal axons formed terminal bulbs that persisted for weeks and were associated with axonal retraction. There were few signs of corticospinal axonal sprouting or elongation. By 2 months after injury, corticospinal axons near the transection site showed an increased number of probable labeled terminals in the adjacent gray matter. These new terminals may contribute to the persistence of many corticospinal axons near the injury site long after a spinal cord transection. Address correspondence and reprint requests to Dr. Fishman, Department of Neurology and the Veterans Administration Research Laboratories, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201. Supported by NIH training grant NS07155-04 to the Department of Neurology of Columbia University, College of Physicians and Surgeons; by an Associate Investigator Award from the Veterans Administration Research Service (P.S.F.); and by NSF grant BNS-811-0240 (J.P.K.). Accepted for publication January 19, 1984.
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