Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leenders, K. L.
Right arrow Articles by McKenzie, C. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leenders, K. L.
Right arrow Articles by McKenzie, C. G.
NEUROLOGY 1985;35:1610
© 1985 American Academy of Neurology

Dexamethasone treatment of brain tumor patients

Effects on regional cerebral blood flow, blood volume, and oxygen utilization

K. L. Leenders, R. P. Beaney, D. J. Brooks, A. A. Lammertsma, J. D. Heather and C. G. McKenzie

From the MHC Cyclotron Unit, Hammersmith Hospital, London. UK

Regional values for cerebral blood flow, blood volume, oxygen extraction fraction, and oxygen utilization were measured, using PET, in 10 brain tumor patients before and after treatment with dexamethasone. Dexamethasone treatment decreased cerebral blood flow and blood volume and increased the fractional extraction of oxygen throughout the brain without affecting oxygen utilization. Dexamethasone probably causes direct vasoconstriction of cerebral blood vessels.

Address correspondence and reprint requests to Dr. Leenders, MRC Cyclotron Unit, Hammersmith Hospital, Ducane Road, London W12 OHS, UK.

Accepted for publication March 7, 1985




This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
M.E. Bastin, T.K. Carpenter, P.A. Armitage, S. Sinha, J.M. Wardlaw, and I.R. Whittle
Effects of dexamethasone on cerebral perfusion and water diffusion in patients with high-grade glioma.
AJNR Am. J. Neuroradiol., February 1, 2006; 27(2): 402 - 408.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
D. J. Covarrubias, B. R. Rosen, and M. H. Lev
Dynamic Magnetic Resonance Perfusion Imaging of Brain Tumors
Oncologist, September 1, 2004; 9(5): 528 - 537.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. W. Norris
Steroids May Have a Role in Stroke Therapy
Stroke, January 1, 2004; 35(1): 228 - 229.
[Full Text] [PDF]

Home page
 Neuro Oncol DukeHome page
M. A. Badruddoja, H. G.J. Krouwer, S. D. Rand, K. J. Rebro, A. P. Pathak, and K. M. Schmainda
Antiangiogenic effects of dexamethasone in 9L gliosarcoma assessed by MRI cerebral blood volume maps
Neuro-oncol, October 1, 2003; 5(4): 235 - 243.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. D. Sysyn, K. H. Petersson, C. S. Patlak, G. B. Sadowska, and B. S. Stonestreet
Effects of postnatal dexamethasone on blood-brain barrier permeability and brain water content in newborn lambs
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R547 - R553.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. M. Rozental, R. L. Levine, R. J. Nickles, and J. A. Dobkin
Glucose Uptake by Gliomas After Treatment: A Positron Emission Tomographic Study
Arch Neurol, December 1, 1989; 46(12): 1302 - 1307.
[Abstract] [PDF]

Home page
 Palliat MedHome page
S. Kirkham
The palliation of cerebral tumours with high-dose dexamethasone: a review
Palliative Medicine, January 1, 1988; 2(1): 27 - 33.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by AAN Enterprises, Inc.