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Effect of gamma-vinyl GABA on human pattern evoked visual potentials

From the Neurology and Medical Research Services, Veterans Administration Medical Center, and the Departmant of Neurology, University of Florida, Gainesville, FL.

We studied the effects on human visual evoked potentials of gamma-vinyl GABA, an anticonvulsant drug that increases cerebral levels of gamma-aminobutyric acid. The subjects were 15 epileptic patients undergoing a clinical trial of this drug. Serial recordings were made from each patient periodically for 1 year. The stimulus was a reversing checkerboard pattern with a check size of 50 minutes. Plasma levels of other antiepileptic medications remained constant throughout the study. No changes, other than a normal variation of ±5 msec, were observed in peak latency throughout the study. These results indicate that there are no GABA-ergic effects on the P100 component evoked by large checkerboard pattern-reversal.

Address correspondence and reprint requests to Dr. Hammond, Neurology Service (127), Veterans Administration Medical Center, Gainesville, FL 32602.

Supported by the Medical Research Service of the Veterans Administration and the Epilepsy Research Foundation of Florida, Inc.

Accepted for publication March 14, 1985.