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Positron emission tomography in the newborn

Effect of seizure on regional cerebral blood flow in an asphyxiated infant

Departments of Pediatrics, Neurology and Neurosurgery, and Riolngical Chemistry, and McDonnell Center of Higher Brain Funrtion, Washington University School of Medicine, St. Louis, MO.

Regional cerebral blood flow (CBF) was measured by positron emission tomography (PET) with ¹⁵O-labeled water in an asphyxiated infant during a seizure. After intrauterine asphyxia, the infant had a syndrome characteristic of hypoxic-ischemic encephalopathy. During a PET scan on the second postnatal day, the infant had a focal seizure with deviation of eyes to the right and clonic jerking of the right arm. Regional blood flow was highest, about 80 m1/100 g/min, in the left temporal-parietal-frontal region of the left hemisphere, the site of origin of the seizure; blood flow in the same region on the other side was about 57 m1/100 g/min. These observations extend to the newborn previous demonstrations in older patients of a focal increase of CBF at the cerebral site of origin of a focal seizure.

Address correspondence end reprint requests to Dr. Volpe, St. Louis Children's Hospital. 400 South Kingshighway. St. Louis, MO 63110.

Accepted for publication June 12. 1984

This article has been cited by other articles:

				D. Evans and M. Levene Neonatal seizures Arch. Dis. Child. Fetal Neonatal Ed., January 1, 1998; 78(1): 70F - 75. [Full Text]

				D. L. Coulter A Proposal for the Description of Neonatal Seizures J Child Neurol, January 1, 1986; 1(1): 79 - 79. [PDF]